ASD can develop either before or after birth just like a cerebral palsy disease. A child suffering from such a disease can’t communicate and interact like normal people.
Autism disease or Autism Spectrum Disorder (ASD) is a combination of neurological disorders. Promising Opportunities for Treating Neurodegenerative Diseases with Mesenchymal Stem Cell-Derived Exosomes.Is your child not capable of communicating properly? Do you observe your child experiencing difficulties in social interactions? If yes, you and your child aren’t the first ones with these neurodevelopmental disorders. Autism - A Comprehensive Array of Prominent Signs and Symptoms. Khan, Aftab Ahmad, Mujaddad Ur Rehman, Imran Kazmi. Muhammad Shahid Nadeem, Bibi Nazia Murtaza, Maryam A.
Veterinary Research Communications 2022, 46 Impact of donor nutritional balance on the growth and development of mesenchymal stem cells from caprine umbilical cord Wharton´s jelly. Juliana Paula Martins Alves, Rafael Rossetto, César Carneiro Linhares Fernandes, Assis Rubens Montenegro, Iolly Tábata Oliveira Marques, Camila Muniz Cavalcanti, Alessandra Façanha Bezerra, Ana Paula Ribeiro Rodrigues, Marcelo Bertolini, Davide Rondina.Neuroscience & Biobehavioral Reviews 2022, 135, 104582. Tiny in size, big in impact: Extracellular vesicles as modulators of mood, anxiety and neurodevelopmental disorders. Eduardo Duarte-Silva, Alice Chevrollier Oriá, Ingrid Prata Mendonça, Michel Gomes de Melo, Igor Henrique R.Intranasal Delivery of Functionalized Polymeric Nanomaterials to the Brain. Frontiers in Molecular Neuroscience 2022, 15
Current Status of Mesenchymal Stem/Stromal Cells for Treatment of Neurological Diseases. da Silva-Junior, Fernanda Gubert, Girlaine Café Santos, Thaís Alves de Santana, Gabriela Louise Almeida Sampaio, Daniela Nascimento Silva, Massimo Dominici, Rosalia Mendez-Otero. The Egyptian Journal of Neurology, Psychiatry and Neurosurgery 2022, 58 Neuroinflammation in autism spectrum disorders: potential target for mesenchymal stem cell-based therapy. This work thereby reports brain-specific delivery of hUC-MSC exosomes, as a cell-free therapy to relieve autism-related phenotypes, providing a promising direction for the treatment of mental development disorders. The therapeutic efficacy can be attributed at least partially to the anti-inflammatory effect of the MSC exosomes. Exosomes from human umbilical cord mesenchymal stem cells (hUC-MSCs) that efficiently enter the brain tissue through the intranasal route restore the social ability of the mice and correct the repeated stereotyped behaviors and other abnormal phenotypes in the offspring of valproic acid (VPA)-treated mice, which show autism-like symptoms. This then inspires us to explore the intranasal delivery of MSC exosomes to brain tissues for the treatment of ASD. Exosomes, for example, the secreted organelles from MSCs, carry bioactive molecules of the MSCs that are essential for the therapeutic effects in ASD treatment. However, the therapeutic efficacy of the MSC transplants was primarily associated with the signals and molecules secreted by the MSCs. Animal experiments and clinical studies have shown that transplantation of mesenchymal stem cells (MSCs) has a positive effect on the treatment of autism spectrum disorder (ASD). Recent breakthroughs in the field of stem cell therapy have brought hope to the treatment of mental diseases.